Tilman Schneider-Poetsch

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Tilman Schneider-Poetsch

Tilman Schneider-Poetsch

Name

Tilman Schneider-Poetsch

Position

Senior Staff Scientist (専任研究員)

E-mail

tsp[at]riken.jp

Education

2009	The Johns Hopkins University School of Medicine
	Doctor of Philosophy Biochemistry, Cell and Molecular Biology (BCMB) Graduate Program Department of Pharmacology and Molecular Sciences
2003	University of California at Berkeley
	Bachelor of Arts in Molecular Cell Biology with emphasis in Biochemistry and Molecular Biology Minor in Chemistry Departmental Honors, Distinction in Scholarship

Research Interest

Chemical Biology of Gene Expression

Recent Publications

Schneider-Poetsch T^‡, Dang Y, Iwasaki I, Arata M, Shichino Y, Al Mourabit A, Moriou C, Romo D, Liu JO, Iwasaki S, Yoshida M, Girolline is a sequence-selective modulator of eIF5A. Nature Commun. 2025 Jan 10;16:223

Saito H, Handa Y, Chen M, Schneider-Poetsch T, Shichino Y, Takahashi M, Romo D, Yoshida M, Fürstner A, Ito T, Fukuzawa K, Iwasaki S. DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs.Nat Commun. 2024 Sep 2;15(1):7418. doi: 10.1038/s41467-024-51635-9.

Sasaki K, Suzuki M, Sonoda T, Schneider-Poetsch T, Ito A, Takagi M, Fujishiro S, Sohtome Y, Dodo K, Umehara T, Aburatani H, Shin-Ya K, Nakao Y, Sodeoka M, Yoshida M. Cell Chem Biol. Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells. Cell Chem Biol. 2022 Jul 21;29(7):1153-1161.e5. doi: 10.1016/j.chembiol.2022.05.006. Epub 2022 Jun 20.

Chhipi-Shrestha JK, Schneider-Poetsch T, Suzuki T, Mito M, Khan K, Dohmae N, Iwasaki S, Yoshida M. Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns. Cell Chem Biol. 2022 Feb 17;29(2):259-275.e10. doi: 10.1016/j.chembiol.2021.07.015. Epub 2021 Sep 13.

Schneider-Poetsch T, Chhipi-Shrestha JK, Yoshida M. Splicing modulators: on the way from nature to clinic. J Antibiot (Tokyo). 2021 Oct;74(10):603-616. doi: 10.1038/s41429-021-00450-1. Epub 2021 Aug 3.

Most frequently cited publication

Schneider-Poetsch T, Ju J, Eyler D, Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO: Inhibition of Eukaryotic Translation Elongation by Cycloheximide and Lactimidomycin. Nature Chem Biol. 2010;6(3):210-217

^‡ denotes corresponding authorship

Book chapter

Schneider-Poetsch T, Yoshida M, Splicing Inhibitors: From small molecule to RNA metabolism, in: Chemical Biology – Concepts and Case Studies, 30 June 2014, Wiley-VCH

Recent Presentations

12 September 2024	Sequence-Selective Modulation of Protein Synthesis Through a Marine Natural Product. Special Seminar, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, USA
2-7 September 2024	Girolline is a Sequence-Selective Modulator of eIF5A. Poster Presentation at the Cold Spring Harbor Laboratories Conference on Translational Control, Cold Spring Harbor, USA
26 June 2024	Girolline is a sequence-selective modulator of translation factor eIF5A. Oral Presentation at the 25^th Annual Meeting of the RNA Society of Japan
29 May 2024	Girolline is a sequence-selective modulator of translation factor eIF5A. Oral Presentation at the 18^th Annual Meeting of the Japanese Society for Chemical Biology
26 March 2024	Girolline is a sequence-selective modulator of translation factor eIF5A. Oral Presentation at the Annual Meeting of the The Japan Society for Bioscience, Biotechnology and Agrochemistry

Funding

FY2025-2027 RIKEN, Shorei Incentive Research Grant

FY 2021-2023 RIKEN, Shorei Incentive Research Grant

Awards

October 2024 The 2022 Ōmura Award for Excellence, Review Article Division,The Journal of Antibiotics

Teaching

Since April 2014

Part-time Lecturer
Waseda University
School of Advanced Science and Engineering
“Introduction to Chemical Biology” as part of Waseda University’s International Program

Languages

Fluent in German and English, advanced skills in Japanese (JLPT N1) and limited proficiency in Latin, French and Russian

Tilman Schneider-Poetsch

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