Representative publications

1. Molecular nanocarbon chemistry
(A28)  “Methylene-bridged [6]-, [8]-, and [10]cycloparaphenylenes: Size-dependent properties and paratropic belt currents” H. Kono et al.J. Am. Chem. Soc. 2023, 145, 8939-8946.
(A27)  “Synthesis, properties, and material hybridization of bare aromatic polymers enabled by dendrimer support” S. Fujiki et al.Nature Commun. 2022, 13, 5358.
(A26)  “Perfluorocycloparaphenylenes” H. Shudo et al.Nature Commun. 2022, 13, 3713.
(A25)  “Synthesis of a Möbius carbon nanobelt” Y. Segawa et al.Nature Synth. 2022,1, 535-541.
(A24)  “Infinitene: A helically twisted figure-eight [12]circulene topoisomer” M. Krzeszewski et al.J. Am. Chem. Soc. 2022, 144, 862-871.
(A23)  “Diversity-oriented synthesis of nanographenes enabled by dearomative annulative π-extension” W. Matsuoka et al.Nature Commun. 2021, 12, 3940.
(A22)  “Double-helix supramolecular nanofibers assembled from negatively curved nanographenes” K. Kato et al.J. Am. Chem. Soc. 2021, 143, 5465-5469.
(A21)  “Synthesis of a zigzag carbon nanobelt” K. Y. Cheung et al.Nature Chem. 2021, 13, 255-259.
(A20)  “Chemical synthesis of carbon nanorings and nanobelts” Y. Li et al.Acc. Mater. Res. 2021, 2, 681-691.
(A19)  “Creation of negatively curved polyaromatics enabled by annulative coupling that forms an eight-membered ring” S. Matsubara et al.Nature Catal. 2020, 3, 710-718.
(A18)  “A nonalternant aromatic belt: Methylene-bridged [6]cycloparaphenylene synthesized from pillar[6]arene” Y. Li et al.J. Am. Chem. Soc. 2020, 142, 12850-12856.
(A17)  “Topologically unique molecular nanocarbons” Y. Segawa et al.Acc. Chem. Res. 2019, 52, 2760-2767.
(A16)  “Topological molecular nanocarbons: all-benzene catenane and trefoil knot” Y. Segawa et al.Science 2019, 365, 272-276.
(A15)  “Strength of carbon nanotubes depends on their chemical structures” A. Takakura et al.Nature Commun. 2019, 10, 3040.
(A14)  “Polycyclic arene synthesis by annulative π-extension” H. Ito et al.J. Am. Chem. Soc. 2019, 141, 3-10.
(A13)  “Ultra-narrow-band thermal exciton radiation in intrinsic one-dimensional semiconductors” T. Nishihara et al.Nature Commun. 2018, 9, 3144. 05598-3
(A12)  “A water-soluble warped nanographene: Synthesis and applications for photo-induced cell death” H.-A. Lin et al.Angew. Chem. Int. Ed. 2018, 57, 2874-2878.
(A11)  “Synthesis of partially and fully fused polyaromatics by annulative chlorophenylene dimerization” Y. Koga et al.Science 2018, 359, 435-439.
(A10)  “Electrically activated conductivity and white light emission of a hydrocarbon nanoring-iodine assembly” N. Ozaki et al.Angew. Chem. Int. Ed. 2017, 56, 11196-11202.
(A9)    “Synthesis of a carbon nanobelt” G. Povie et al.Science 2017, 356, 172-175.
(A8)    “Synthesis and structural features of quadruple helicenes: Highly distorted π systems enabled by accumulation of helical repulsions” T. Fujikawa et al.J. Am. Chem. Soc. 2016, 138, 3587-3595.
(A7)    “Structurally uniform and atomically precise carbon nanostructures” Y. Segawa et al.Nature Rev. Mat. 2016, 1, 15002.
(A6)    “One-shot K-region-selective annulative π-extension for nanographene synthesis and functionalization” K. Ozaki et al.Nature Commun. 2015, 6, 6251.
(A5)    “All-benzene carbon nanocages: Size-selective synthesis, photophysical properties, and crystal structure” K. Matsui et al.J. Am. Chem. Soc. 2014, 136, 16452-16458.
(A4)    “A grossly warped nanographene and the consequences of multiple odd-membered-ring defects” K. Kawasumi et al.Nature Chem. 2013, 5, 739-744.
(A3)    “Initiation of carbon nanotube growth by well-defined carbon nanorings” H. Omachi et al.Nature Chem. 2013, 5, 572-576.
(A2)    “Synthesis of cycloparaphenylenes and related carbon nanorings: A step toward the controlled synthesis of carbon nanotubes” H. Omachi et al.Acc. Chem. Res. 2012, 45, 1378-1389.
(A1)    “Selective synthesis of [12]cycloparaphenylene” H. Takaba et al.Angew. Chem. Int. Ed. 2009, 48, 6112-6116.

2. Synthetic methodology
(B23)  “Lithium-mediated mechanochemical cyclodehydrogenation” K. Fujishiro et al.J. Am. Chem. Soc. 2023, 145, 8163-8175.
(B22)  “π-Extended rubrenes via dearomative annulative π-extension reaction” W. Matsuoka et al.J. Am. Chem. Soc. 2023, 145, 658-666.
(B21)  “Selective transformation of strychnine and 1,2-disubstituted benzenes by C-H borylation” Y. Saito et al.Chem 2020, 6, 985-993.
(B20)  “Rapid access to nanographenes and fused heteroaromatics by palladium-catalyzed annulative π-extension reaction of unfunctionalized aromatics with diiodobiaryls” W. Matsuoka et al.Angew. Chem. Int. Ed. 2017, 56, 12224-12228.
(B19)  “Annulative π-extension (APEX): An enabling reaction for rapid access to fused aromatics, heteroaromatics, and nanographenes” H. Ito et al.Angew. Chem. Int. Ed. 2017, 56, 11144-11164.
(B18)  “Catalytic dehydrogenative C-H imidation of arenes enabled by photo-generated hole donation to sulfonimide” E. Ito et al.Chem 2017, 2, 383-392.
(B17)  “Decarbonylative organoboron cross-coupling of esters by nickel catalysis” K. Muto et al.Nature Commun. 2015, 6, 7508.
(B16)  “para-C-H borylation of benzene derivatives by a bulky iridium catalyst” Y. Saito et al.J. Am. Chem. Soc. 2015, 137, 5193-5198.
(B15)  “Catalytic C-H imidation of aromatic cores of functional molecules: Ligand-accelerated Cu catalysis and application to materials- and biology-oriented aromatics” T. Kawakami et al.J. Am. Chem. Soc. 2015, 137, 2460-2463.
(B14)  “Synthesis and characterization of hexaarylbenzenes with five or six different substituents enabled by programmed synthesis” S. Suzuki et al.Nature Chem. 2015, 7, 227-233.
(B13)  “Concise syntheses of dictyodendrins A and F by a sequential C-H functionalization strategy” A. D. Yamaguchi et al.J. Am. Chem. Soc. 2015, 137, 644-647.
(B12)  “C-H bond functionalization: Emerging synthetic tools for natural products and pharmaceuticals” J. Yamaguchi et al.Angew. Chem. Int. Ed. 2012, 51, 8960-9009.
(B11)  “Decarbonylative C-H coupling of azoles and aryl esters: Unprecedented nickel catalysis and application to the synthesis of muscoride A” K. Amaike et al.J. Am. Chem. Soc. 2012, 134, 13573-13576.
(B10)  “Nickel-catalyzed C-H/C-O coupling of azoles with phenol derivatives” K. Muto et al.J. Am. Chem. Soc. 2012, 134, 169-172.
(B9)    “Direct aylation of polycyclic aromatic hydrocarbons through palladium catalysis” K. Mochida et al.J. Am. Chem. Soc. 2011, 133, 10716-10719.
(B8)   “A general catalyst for the beta-selective C-H bond arylation of thiophenes with iodoarenes” K. Ueda et al.Angew. Chem. Int. Ed. 2010, 49, 8946-8949.
(B7)   “Programmed synthesis of tetraarylthiophenes through sequential C-H arylation” S. Yanagisawa et al.J. Am. Chem. Soc. 2009, 131, 14622-14623.
(B6)   “Potassium t-butoxide alone can promote the biaryl coupling of electron-deficient nitrogen heterocycles and haloarenes” S. Yanagisawa et al.Org. Lett. 2008, 10, 4673-4676.
(B5)   “Rh-catalyzed arylation and alkenylation of C60 using organoboron compounds” M. Nambo et al.J. Am. Chem. Soc. 2007, 129, 8080-8081.
(B4)   “Direct C-H arylation of (hetero)arenes with aryl iodides via rhodium catalysis” S. Yanagisawa et al.J. Am. Chem. Soc. 2006, 128, 11748-11749.
(B3)   “Triarylethene-based extended π-systems: Programmable synthesis and photophysical properties” K. Itami et al.J. Org. Chem. 2005, 70, 2778-2792.
(B2)   “Sequential assembly strategy for tetrasubstituted olefin synthesis using vinyl 2-pyrimidyl sulfide as a platform” K. Itami et al.J. Am. Chem. Soc. 2004, 126, 11778-11779.
(B1)   “Diversity-oriented synthesis of multisubstituted olefins through the sequential integration of palladium-catalyzed cross-coupling reactions. 2-Pyridyldimethyl(vinyl)silane as a versatile platform for olefin synthesis” K. Itami et al.J. Am. Chem. Soc. 2001, 123, 11577-11585.

3. Chemical chronobiology
(C7)    “Reversible modulation of circadian time with chronophotopharmacology” D. Kolarski et al.Nature Commun. 2021, 12, 3164.
(C6)    “Photopharmacological manipulation of mammalian CRY1 for regulation of the circadian clock”  D. Kolarski et al.J. Am. Chem. Soc. 2021, 143, 2078-2087.
(C5)    “Small molecules modulating mammalian biological clocks: Exciting new opportunities for synthetic chemistry” K. Amaike et al.Chem 2020, 6, 2186-2198.
(C4)    “Isoform-selective regulation of mammalian cryptochromes” S. Miller et al.Nature Chem. Biol. 2020, 16, 676-685.
(C3)    “Controlling the circadian clock with high temporal resolution through photodosing” J. Am. Chem. Soc. 2019, 141, 15784-15791.
(C2)    “Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth” T. Oshima et al.Science Adv. 2019, 5, eau9060.
(C1)    “C-H activation generates period-shortening molecules that target Cryptochrome in the mammalian circadian clock” T. Oshima et al.Angew. Chem. Int. Ed. 2015, 54, 7193-7197.

4. Plant chemical biology
(D9)    “Discovery of 2,6-dihalopurines as stomata opening inhibitors: Implication of an LRX-mediated H+-ATPase phosphorylation pathway” A. Ueda et al.ACS Chem. Biol. 2023, 18, 347-355.
(D8)    “Identification of stomatal-regulating molecules from de novo arylamine collection through aromatic C-H amination” Y. Toda et al.Sci. Rep. 2022, 12, 949.
(D7)    “Casein kinese 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock” T. N Uehara et al.Proc. Nat. Acad. Sci. 2019, 116, 11528-11536.
(D6)    “Discovery of plant growth stimulants by C-H arylation of 2-azahypoxanthine” H. Kitano et al.Org. Lett. 2018, 20, 5684-5687.
(D5)    “Discovery of shoot branching regulator targeting strigolactone receptor DWARF14” M. Yoshimura et al.ACS Cent. Sci. 2018, 4, 230-234.
(D4)    “Chemical hijacking of auxin signaling with an engineered auxin-TIR1 pair” N. Uchida et al.Nature Chem. Biol. 2018, 14, 299-305.
(D3)    “Discovery of synthetic small molecules that enhance the number of stomata: C-H functionalization chemistry for plant biology” A. Ziadi et al.Chem. Commun. 2017, 53, 9632-9635.
(D2)    “The AMOR arabinogalactan sugar chain induces pollen-tube competency to respond to ovular guidance” A. G. Mizukami et al.Curr. Biol. 2016, 26, 1091-1097.
(D1)    “Probing strigolactone receptors in Striga hermonthica with fluorescence” Y. Tsuchiya et al.Science 2015, 349, 864-868.