English
Name
シュナイダー・ポーチュ ティルマン
Tilman Schneider-Poetsch
Position
専任研究員
tsp[at]riken.jp
Education
| 2009 | The Johns Hopkins University School of Medicine |
| Doctor of Philosophy Biochemistry, Cell and Molecular Biology (BCMB) Graduate Program Department of Pharmacology and Molecular Sciences |
|
| 2003 | University of California at Berkeley |
| Bachelor of Arts in Molecular Cell Biology with emphasis in Biochemistry and Molecular Biology Minor in Chemistry Departmental Honors, Distinction in Scholarship |
Research Interest
Chemical Biology of Gene Expression
Recent Publications
Schneider-Poetsch T‡, Dang Y, Iwasaki I, Arata M, Shichino Y, Al Mourabit A, Moriou C, Romo D, Liu JO, Iwasaki S, Yoshida M, Girolline is a sequence-selective modulator of eIF5A. Nature Commun. 2025 Jan 10;16:223
Saito H, Handa Y, Chen M, Schneider-Poetsch T, Shichino Y, Takahashi M, Romo D, Yoshida M, Fürstner A, Ito T, Fukuzawa K, Iwasaki S. DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs.Nat Commun. 2024 Sep 2;15(1):7418. doi: 10.1038/s41467-024-51635-9.
Sasaki K, Suzuki M, Sonoda T, Schneider-Poetsch T, Ito A, Takagi M, Fujishiro S, Sohtome Y, Dodo K, Umehara T, Aburatani H, Shin-Ya K, Nakao Y, Sodeoka M, Yoshida M. Cell Chem Biol. Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells. Cell Chem Biol. 2022 Jul 21;29(7):1153-1161.e5. doi: 10.1016/j.chembiol.2022.05.006. Epub 2022 Jun 20.
Chhipi-Shrestha JK, Schneider-Poetsch T, Suzuki T, Mito M, Khan K, Dohmae N, Iwasaki S, Yoshida M. Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns. Cell Chem Biol. 2022 Feb 17;29(2):259-275.e10. doi: 10.1016/j.chembiol.2021.07.015. Epub 2021 Sep 13.
Schneider-Poetsch T, Chhipi-Shrestha JK, Yoshida M. Splicing modulators: on the way from nature to clinic. J Antibiot(Tokyo). 2021 Oct;74(10):603-616. doi: 10.1038/s41429-021-00450-1. Epub 2021 Aug 3.
Most frequently cited publication
Schneider-Poetsch T, Ju J, Eyler D, Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO: Inhibition of Eukaryotic Translation Elongation by Cycloheximide and Lactimidomycin. Nature Chem Biol. 2010;6(3):210-217
‡ denotes corresponding authorship
Book chapter
Schneider-Poetsch T, Yoshida M, Splicing Inhibitors: From small molecule to RNA metabolism, in: Chemical Biology – Concepts and Case Studies, 30 June 2014, Wiley-VCH
Recent Presentations
| 12 September 2024 | Sequence-Selective Modulation of Protein Synthesis Through a Marine Natural Product. Special Seminar, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, USA |
| 2-7 September 2024 | Girolline is a Sequence-Selective Modulator of eIF5A. Poster Presentation at the Cold Spring Harbor Laboratories Conference on Translational Control, Cold Spring Harbor, USA |
| 26 June 2024 | Girolline is a sequence-selective modulator of translation factor eIF5A. Oral Presentation at the 25th Annual Meeting of the RNA Society of Japan |
| 29 May 2024 | Girolline is a sequence-selective modulator of translation factor eIF5A. Oral Presentation at the 18th Annual Meeting of the Japanese Society for Chemical Biology |
| 26 March 2024 | Girolline is a sequence-selective modulator of translation factor eIF5A. Oral Presentation at the Annual Meeting of the The Japan Society for Bioscience, Biotechnology and Agrochemistry |
Funding
FY2025-2027 RIKEN, Shorei Incentive Research Grant
FY 2021-2023 RIKEN, Shorei Incentive Research Grant
Awards
October 2024 The 2022 Ōmura Award for Excellence, Review Article Division,The Journal of Antibiotics
Teaching
| Since April 2014 | Part-time Lecturer Waseda University School of Advanced Science and Engineering “Introduction to Chemical Biology” as part of Waseda University’s International Program |
Languages
Fluent in German and English, advanced skills in Japanese (JLPT N1) and limited proficiency in Latin, French and Russian
