English
Name
シュナイダー・ポーチュ ティルマン
Tilman Schneider-Poetsch
Position
専任研究員
tsp[at]riken.jp
Education
| 2009 | The Johns Hopkins University School of Medicine |
| Doctor of Philosophy Biochemistry, Cell and Molecular Biology (BCMB) Graduate Program Department of Pharmacology and Molecular Sciences |
|
| 2003 | University of California at Berkeley |
| Bachelor of Arts in Molecular Cell Biology with emphasis in Biochemistry and Molecular Biology Minor in Chemistry Departmental Honors, Distinction in Scholarship |
Research Interest
Chemical Biology of Gene Expression
Recent Publications
Schneider-Poetsch T‡, Dang Y, Iwasaki I, Arata M, Shichino Y, Al Mourabit A, Moriou C, Romo D, Liu JO, Iwasaki S, Yoshida M, Girolline is a sequence-selective modulator of eIF5A. Nature Commun. 2025 Jan 10;16:223
Saito H, Handa Y, Chen M, Schneider-Poetsch T, Shichino Y, Takahashi M, Romo D, Yoshida M, Fürstner A, Ito T, Fukuzawa K, Iwasaki S. DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs.Nat Commun. 2024 Sep 2;15(1):7418. doi: 10.1038/s41467-024-51635-9.
Sasaki K, Suzuki M, Sonoda T, Schneider-Poetsch T, Ito A, Takagi M, Fujishiro S, Sohtome Y, Dodo K, Umehara T, Aburatani H, Shin-Ya K, Nakao Y, Sodeoka M, Yoshida M. Cell Chem Biol. Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells. Cell Chem Biol. 2022 Jul 21;29(7):1153-1161.e5. doi: 10.1016/j.chembiol.2022.05.006. Epub 2022 Jun 20.
Chhipi-Shrestha JK, Schneider-Poetsch T, Suzuki T, Mito M, Khan K, Dohmae N, Iwasaki S, Yoshida M. Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns. Cell Chem Biol. 2022 Feb 17;29(2):259-275.e10. doi: 10.1016/j.chembiol.2021.07.015. Epub 2021 Sep 13.
Schneider-Poetsch T, Chhipi-Shrestha JK, Yoshida M. Splicing modulators: on the way from nature to clinic. J Antibiot(Tokyo). 2021 Oct;74(10):603-616. doi: 10.1038/s41429-021-00450-1. Epub 2021 Aug 3.
Most frequently cited publication
Schneider-Poetsch T, Ju J, Eyler D, Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO: Inhibition of Eukaryotic Translation Elongation by Cycloheximide and Lactimidomycin. Nature Chem Biol. 2010;6(3):210-217
‡ denotes corresponding authorship
Book chapter
Schneider-Poetsch T, Yoshida M, Splicing Inhibitors: From small molecule to RNA metabolism, in: Chemical Biology – Concepts and Case Studies, 30 June 2014, Wiley-VCH
Recent Presentations
| 1 December 2025 | Girolline as a sequence-selective probe into eIF5A function The 11th Japan-Korea Chemical Biology Symposium, Cheongju, Korea |
| 18 November 2025 | Confusing the translator – on natural product modulators of eukaryotic protein biosynthesis Invited Lecture at Maebashi Institute of Technology, Maebashi, Gunma, Japan https://www.maebashi-it.ac.jp/department/lsi/info/news/_tilman_schneider-poetsch.html |
| 10 November 2025 | Confusing the translator – on natural product modulators of eukaryotic protein biosynthesis Invited Lecture at Utsunomiya University, Utsunomiya, Tochigi, Japan |
| 15 September 2025 | Girolline as a sequence-selective probe into eIF5A function University of Tübingen, Germany, Cluster of Excellence, Controlling Microbes to Fight Infections https://www.cmfi.uni-tuebingen.de/aktuelles/veranstaltungen/girolline-as-a-sequence-selective-probe-into-eif5a-function |
| 9 September 2025 | Girolline as a sequence-selective probe into eIF5A function KU Leuven, Belgium, Department of Chemistry |
| 8 September 2025 | Girolline as a sequence-selective probe into eIF5A function Max Planck Institute for the Biology of Aging, Cologne, Germany https://crc1678.uni-koeln.de/seminar-series/crc-1678-seminar-by-dr-tilman-schneider-poetsch-girolline-as-a-sequence-selective-probe-into-eif5a-function/ |
| 4 September 2025 | Girolline as a probe into eIF5A function EMBL Conference “Protein Synthesis and Translational Control”, EMBL Advanced Training Centre, Heidelberg, Germany https://www.embl.org/about/info/course-and-conference-office/events/trc25-01/ |
| 12 September 2024 |
Sequence-Selective Modulation of Protein Synthesis Through a Marine Natural Product. Special Seminar, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, USA |
| 2-7 September 2024 | Girolline is a Sequence-Selective Modulator of eIF5A. Poster Presentation at the Cold Spring Harbor Laboratories Conference on Translational Control, Cold Spring Harbor, USA (Poster) |
| 26 June 2024 | Girolline is a sequence-selective modulator of translation factor eIF5A. Oral Presentation at the 25th Annual Meeting of the RNA Society of Japan |
| 29 May 2024 | Girolline is a sequence-selective modulator of translation factor eIF5A. Oral Presentation at the 18th Annual Meeting of the Japanese Society for Chemical Biology |
| 26 March 2024 | Girolline is a sequence-selective modulator of translation factor eIF5A. Oral Presentation at the Annual Meeting of the The Japan Society for Bioscience, Biotechnology and Agrochemistry |
Funding
FY2025-2027 RIKEN, Shorei Incentive Research Grant
FY 2021-2023 RIKEN, Shorei Incentive Research Grant
FY 2016-2017 Kakenhi, Wakate (B), Chemical Biology of small RNA histone modifiers
Awards
October 2024 The 2022 Ōmura Award for Excellence, Review Article Division,The Journal of Antibiotics
September 2015 Poster Award at the 40th Naito Conference, “Epigenetics – from Histone Code to Therapeutic Strategy”
Teaching
| Since April 2014 | Part-time Lecturer Waseda University School of Advanced Science and Engineering “Introduction to Chemical Biology” as part of Waseda University’s International Program |
Languages
Fluent in German and English, advanced skills in Japanese (JLPT N1) and limited proficiency in Latin, French and Russian
