Name

Kazuma Amaike

Mail Address

kazuma.amaike[at]riken.jp

Research Interest

Chemical biology

Education

2007~2011　B.S. in Chemistry, Nagoya University (Advisor: Prof. Kenichiro Itami)

2011~2013　M.S. in Chemistry, Nagoya University (Advisor: Prof. Kenichiro Itami)

2013~2016　Ph.D. in Chemistry, Nagoya University (Advisor: Prof. Kenichiro Itami)

2013~2016　JSPS Research Fellowship for Young Scientists (DC1)

2013.4~2013.7   Exchange Student, MIT (Prof. Mohammad Movassaghi）

Academic career

2016.4~2019.6　Postdoctoral Researcher, Graduate School of Engineering, Kyoto University (Prof. Itaru Hamachi)

2017.4~2019.6　JSPS Research Fellowship for Young Scientists (SPD)

2019.7~2021.3　Designated Assistant Professor, Graduate School of Science, Nagoya University (with Prof. Kenichiro Itami)

2021.4~2024.7　Assistant Professor, Research Center for Materials Science, Nagoya University (with Prof. Kenichiro Itami)

2023.4~2024.7　Young Researcher Unit, Nagoya University

2024.8~　　       Research Scientist, RIKEN Cluster for Pioneering Research (with Chief Scientist Kenichiro Itami)

Awards

2023　ITbM Research Award
2019　Nippon Shokubai Co. Award in Synthetic Organic Chemistry
2018　CSJ Presentation Award
2015　ITbM/IGER Chemistry Workshop Poster award
2014　Otsu Conference Award Fellow（No.071）

 

Publications

【Article】
(21) C–H Amination of Unactivated Arenes Through a Dearomative (3+2) Cycloaddition
Sajan Pradhan, Fahimeh Mohammadi, Rikuo Tanase, Kazuma Amaike, Kenichiro Itami, Jean Bouffard
ChemRxiv, 2024, DOI: 10.26434/chemrxiv-2024-mj889

(20) Water-soluble aromatic nanobelt with unique cellular internalization
Konstantin Günther, Hideya Kono, Hiroki Shudo, Daisuke Shimizu, Reika Isoda, Masayoshi Nakamura, Akiko Yagi,* Kazuma Amaike,* Kenichiro Itami*
ChemRxiv, 2024, DOI: 10.26434/chemrxiv-2024-vv4nb

(19) In-insect synthesis of oxygen-doped molecular nanocarbons
Atsushi Usami, Hideya Kono, Vic Austen, Quan Manh Phung, Hiroki Shudo, Tomoki Kato, Hayato Yamada, Akiko Yagi, Kazuma Amaike, Kazuhiro Fujimoto, Takeshi Yanai, Kenichiro Itami
ChemRxiv, 2024, DOI: 10.26434/chemrxiv-2024-1zd0b

(18) Nickel/Photoredox-Catalyzed Decarboxylative Coupling of Aryl Bromides with N-Protected Glycine as an Aminomethyl Source
Jaehyun Jung, Takumi Kinoshita, Yuta Makihara, Yota Sakakibara, Kazuma Amaike, Kei Murakami, Kenichiro Itami
Synlett 2024, 35, 337–341. DOI: 10.1055/s-0041-1738444

(17) Development of a novel PET ligand, [¹¹C]GO289 targeting CK2 expressed in the brain
Aya Ogata, Takashi Yamada, Saori Hattori, Hiroshi Ikenuma, Junichiro Abe, Mari Tada, Masanori Ichise, Masaaki Suzuki, Kengo Ito, Takashi Kato, Kazuma Amaike, Tsuyoshi Hirota, Akiyoshi Kakita, Kenichiro Itami, Yasuyuki Kimura
Bioorg. Med. Chem. Lett. 2023, 90, 129327. DOI: 10.1016/j.bmcl.2023.129327

(16) C-H arylation enables synthesis of imidazole-4-carboxamide (ICA) based fairy chemicals with plant growth promoting activity
Ayaka Ueda, Kazuma Amaike,* Yoko Shirotani, Robin Warstat, Hideto Ito, Jae-Hoon Choi, Hirokazu Kawagishi,* Kenichiro Itami*
Can. J. Chem. 2023, 101, 449–452. DOI:10.1139/cjc-2022-0256

(15) Discovery of 2,6-Dihalopurines as Stomata Opening Inhibitors: Implication of an LRX-mediated H⁺-ATPase Phosphorylation Pathway
Ayaka Ueda, Yusuke Aihara, Shinya Sato, Keiko Kano, Emi Mishiro-Sato, Hiroyuki Kitano, Ayato Sato, Kazuhiro J. Fujimoto,* Takeshi Yanai, Kazuma Amaike,* Toshinori Kinoshita,* Kenichiro Itami*
ACS Chemical Biology, 2023, 18, 347–355. DOI:10.1021/acschembio.2c00771; ChemRxiv, 2022, DOI: 10.26434/chemrxiv-2022-6s89g

(14) Synthesis, properties, and material hybridization of bare aromatic polymers enabled by dendrimer support
Shusei Fujiki, Kazuma Amaike, Akiko Yagi, Kenichiro Itami
Nature Communications 2022, 13, 5358. DOI: 10.1038/s41467-022-33100-7

(13) Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution dynamics
Hiroshi Nonaka, Takeharu Mino, Seiji Sakamoto, Jae Hoon Oh, Yu Watanabe, Mamoru Ishikawa, Akihiro Tsushima, Kazuma Amaike, Shigeki Kiyonaka, Tomonori Tamura, A. Radu Aricescu, Wataru Kakegawa, Eriko Miura, Michisuke Yuzaki, Itaru Hamachi
Chem, 2023, 9, 523–540. DOI: 10.1016/j.chempr.2022.11.005; bioRxiv 2021, DOI: 10.1101/2021.12.21.473647

(12) Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock
Dušan Kolarski, Simon Miller, Tsuyoshi Oshima, Yoshiko Nagai, Yugo Aoki, Piermichele Kobauri, Ashutosh Srivastava, Akiko Sugiyama, Kazuma Amaike, Ayato Sato, Florence Tama, Wiktor Szymanski, Ben Feringa, Kenichiro Itami, Tsuyoshi Hirota
J. Am. Chem. Soc. 2021, 143, 4, 2078–2087.　DOI: 10.1021/jacs.0c12280

(11) Effect of nanocarbon molecules on the Arabidopsis thaliana transcriptome
Norihito Nakamichi, Ayato Sato, Yusuke Aihara, Toshinori Kinoshita, Yasutomo Segawa, Kazuma Amaike, Kenichiro Itami
bioRxiv 2020, DOI: 10.1101/2020.05.22.110171

(10) An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals
Simon Miller, Yoshiki Aikawa, Akiko Sugiyama, Yoshiko Nagai, Aya Hara, Tsuyoshi Oshima, Kazuma Amaike, Steve A. Kay, Kenichiro Itami, Tsuyoshi Hirota
Cell Chem. Biol. 2020, 27, 1192–1198.　DOI: 10.1016/j.chembiol.2020.05.008

(9) Construction of a Fluorescent Screening System of Allosteric Modulators for the GABA_A Receptor Using a Turn-On Probe
Seiji Sakamoto, Kei Yamaura, Tomohiro Numata, Fumio Harada, Kazuma Amaike, Ryuji Inoue, Shigeki Kiyonaka, and Itaru Hamachi
ACS Cent. Sci. 2019, 5, 1541–1553.　DOI: 10.1021/acscentsci.9b00539

(8) Affinity-guided oxime chemistry for selective protein acylation in live tissue systems
Tomonori Tamura, Zhining Song, Kazuma Amaike, Shin Lee, Sifei Yin, Shigeki Kiyonaka, and Itaru Hamachi
J. Am. Chem. Soc. 2017, 139, 14181–14191.　DOI: 10.1021/jacs.7b07339

(7) Synthesis of multiply arylated pyridines
Takashi Asako, Wakana Hayashi, Kazuma Amaike, Shin Suzuki, Kenichiro Itami, Kei Muto, and Junichiro Yamaguchi
Tetrahedron 2017, 73, 3669–3676.　DOI: 10.1016/j.tet.2017.03.095

(6) Synthesis of Triarylpyridines in Thiopeptide Antibiotics by Using a C−H Arylation/Ring-Transformation Strategy
Kazuma Amaike, Kenichiro Itami, Junichiro Yamaguchi
Chem. Eur. J. 2016, 22, 4384–4388.　DOI: 10.1002/chem.201600351

(5) Direct C7 Functionalization of Tryptophan. Synthesis of Methyl (S)-2-((tert-Butoxycarbonyl)amino)-3-(7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-3-yl)propanoate
Kazuma Amaike, Richard P. Loach, Mohammad Movassaghi
Org. Synth. 2015, 92, 373–385.　DOI: 10.15227/orgsyn.092.0373

(4) C7-Derivatization of C3-Alkylindoles Including Tryptophans and Tryptamines
Richard P. Loach, Owen S. Fenton, Kazuma Amaike, Dustin S. Siegel, Erhan Ozkal, Mohammad Movassaghi
J. Org. Chem. 2014, 79, 11254–11263.　DOI: 10.1021/jo502062z
Most Read Articles in November 2014

(3) β-Selective C–H Arylation of Pyrroles Leading to Concise Syntheses of Lamellarins C and I
Kirika Ueda, Kazuma Amaike, Richard M. Maceiczyk, Kenichiro Itami, and Junichiro Yamaguchi
J. Am. Chem. Soc. 2014, 136, 13226–13232.　DOI: 10.1021/ja508449y
Most Read Articles in September 2014

(2) Late-Stage C–H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues
Hiromi Sekizawa, Kazuma Amaike, Yukihiro Itoh,  Takayoshi Suzuki, Kenichiro Itami, Junichiro Yamaguchi
ACS. Med. Chem. Lett. 2014, 5, 582–586.　DOI: 10.1021/ml500024s
Most Read Articles in March 2014

(1) Decarbonylative C–H Coupling of Azoles and Aryl Esters: Unprecedented Nickel Catalysis and Application to Synthesis of Muscoride A
Kazuma Amaike, Kei Muto, Junichiro Yamaguchi, Kenichiro Itami
J. Am. Chem. Soc. 2012, 134, 13573–13576.　DOI: 10.1021/ja306062c
Highlighted in Newspapers (Chu-nichi, Asahi, The Chemical Daily, Yahoo!News, Mynavi-News)
Most Read Articles in August 2012

【Review】

(4) Small Molecules Modulating Mammalian Biological Clocks: Exciting New Opportunities for Synthetic Chemistry
Kazuma Amaike, Tsuyoshi Oshima, Nicola Stephanie Skoulding, Yoshifumi Toyama, Tsuyoshi Hirota, Kenichiro Itami
Chem, 2020, 6, 2186-2198. DOI: 10.1016/j.chempr.2020.08.011

(3) AGOX化学による生体組織の内在タンパク質の触媒的ラベリング
天池一真
生体機能関連化学部会NEWS LETTER, 2018, 33, 1, 7–11.

(2) Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding live cells
Kazuma Amaike, Tomonori Tamura, Itaru Hamachi
Chem. Commun., 2017, 53, 11972–11983.　DOI: 10.1039/C7CC07177A

(1) ニッケル触媒を用いたヘテロ芳香族化合物の直接的カップリング
山口 潤一郎, 武藤 慶, 天池 一真, 山本 拓矢, 伊丹 健一郎
有機合成化学協会誌, Vol. 71 (2013), No. 6, 576–587.　DOI: 10.5059/yukigoseikyokaishi.71.576

【書籍】

(2) Synthesis of Natural Products and Pharmaceuticals via Catalytic C–H Functionalization
Junichiro Yamaguchi, Kazuma Amaike and Kenichiro Itami
Transition Metal-Catalyzed Heterocycle Synthesis via C–H Activation, Wiley-VCH book, 2016, 505–550.

(1)「触媒の設計･反応制御 事例集」
ニッケル触媒を用いた新しいクロスカップリング反応とその応用
伊丹 健一郎, 山口 潤一郎, 天池 一真, 武藤 慶

Research Presentation

Invited Lecture

(2) 分子ナノカーボンを用いたケミカルバイオロジー
第448回触媒科学研究所コロキウム、北海道大学、2023年5月9日

(1) Chemical biology in mammalian, plant and insect
ITbM workshop, Nagoya University
2021年4月9日（オンライン）

 

Oral Presentation

(10) Nucleic acid delivery using cationic polycyclic aromatic hydrocarbons
Kazuma Amaike, Erika Kato, Miu Fukatsu, Dominik Zetschok, Luca Hagemeyer, Atsushi Usami, Hayato Yamada, Kenichiro Itami
IKCOC-15, OP-55, Rihga Royal Hotel KYOTO, JAPAN, 2023/11/23 (Contributed Oral Presentation)

(9) カチオン性ペリレンを用いた核酸輸送
天池一真、加藤江莉佳 、深津美羽、Dominik Zetschok、宇佐見享嗣、山田 早人、伊丹健一郎
第16回バイオ関連化学シンポジウム、名古屋大学・東山キャンパス、2022年9月10–12日

(8) 細胞および脳組織における内在性タンパク質の固定化駆動型アフィニティーラベリング
天池一真、山上禎俊、西川雄貴、後藤大輝、清中茂樹、浜地格
日本化学会第99春季年会、甲南大学・岡本キャンパス、2019年3月16–19日

(7) Whole body imaging を指向した固定化剤駆動型のタンパク質可視化法
天池一真、山上禎俊、西川雄貴、清中茂樹、浜地格
日本ケミカルバイオロジー学会第13回年会、東京医科歯科大学、2018年 6月11–13日

(6) A new method for visualizing neurotransmitter receptors by a chemical cross-linking
Kazuma Amaike, Sadatoshi Yamagami, Yuki Nishikawa, Shigeki Kiyonaka, Itaru Hamachi
日本化学会第98春季年会、日本大学理工学部・船橋キャンパス、2018年3月20–23日

(5) オキシム触媒・NASA型アシルドナーを用いた新規affinity-guided protein labeling
天池一真、宋智凝、李伸、田村朋則、浜地格
日本ケミカルバイオロジー学会第12回年会、北海道大学・クラーク会館、2017年6月7–9日

(4) New method for affinity-guided protein labeling
Kazuma Amaike, Zhining Song, Shin Lee, Tomonori Tamura, Itaru Hamachi
日本化学会第97春季年会 、慶應義塾大学・日吉キャンパス、2017年3月16–19日

(3) 新規カップリング反応と環変換反応を鍵としたチオペプチド抗生物質群の迅速合成法の確立
天池一真、武藤慶、伊丹健一郎、山口潤一郎
第57回天然有機化合物討論会、37、神奈川県民ホール、神奈川、2015年9月11日

(2) Rapid Access to Triarylpyridines and Synthesis of GE2270s
Kazuma Amaike, Junichiro Yamaguchi, Kenichiro Itami
第95日本化学会年会、1J2-51、日本大学理工学部 船橋キャンパス／薬学部、千葉、2015年3月26日

(1) Ni触媒を用いたアゾール類と芳香族エステルの芳香環連結反応の開発とmuscoride Aの全合成
天池一真、武藤慶、山口潤一郎、伊丹健一郎
第92日本化学会年会、4L2-38、神奈川、2012年3月28日

 

Poster Presentation

(10) Affinity-guided oxime chemistry for selective protein labeling in brain slices
Kazuma Amaike, Zhining Song, Shin Lee, Tomonori Tamura, Itaru Hamachi
ISBC2017, Kihada Hall, Uji Campus, Kyoto University, JAPAN, December 14–16, 2017.

(9) New affinity-guided protein labeling using oxime catalyst and NASA type acyl donor
天池一真
第2回大津会議合同研究発表会、びわ湖大津プリンスホテル、 2017年9月11–12日

(8) Rapid Access to Triarylpyridines and Synthesis of GE2270s
天池一真、伊丹健一郎、山口潤一郎
ITbM/IGER Chemistry Workshop、30、名古屋大学、2015年10月30日

(7) Rapid Access to Triarylpyridines and Synthesis of GE2270s
Kazuma Amaike, Kenichiro Itami, Junichiro Yamaguchi
Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS-18), P-418, Hotel Meliá Sitges, Sitges (Spain), July 1st, 2015.

(6) Novel Synthetic Method of Triarylpyridines
Kazuma Amaike, Kenichiro Itami, and Junichiro Yamaguchi
ICOMC 2014, 3P131, Sapporo, July 17, 2014.

(5) Decarbonylative C–H Arylation of Azoles with Aromatic Esters through Nickel Catalysis
Kazuma Amaike, Kei Muto, Junichiro Yamaguchi, and Kenichiro Itami
IKCOC-12, PC-013, Kyoto, Nov 15, 2012.

(4) Decarbonylative C–H Arylation of Azoles with Aromatic Esters through Nickel Catalysis
Kazuma Amaike, Kei Muto, Junichiro Yamaguchi, and Kenichiro Itami
The 14th IRTG Symposium, Nagoya University, Oct 2, 2012.

(3) Decarbonylative C–H Arylation of Azoles with Aromatic Esters through Nickel Catalysis
Kazuma Amaike, Kei Muto, Junichiro Yamaguchi, and Kenichiro Itami
International Symposia on Advancing the Chemical Sciences (ISACS7), P77, University of Edinburgh, Jun 13, 2012.

(2) Rapid Access to Trithiazolylpyridines through C–H Arylation: Studies Toward the Synthesis of GE2270A
天池一真、山口潤一郎、伊丹健一郎
第2回統合物質シンポジウム、P03、名古屋大学、2011年11月7-8日

(1) Rapid Access to Trithiazolylpyridines through C–H Arylation: Studies Toward the Synthesis of GE2270A
Kazuma Amaike, Junichiro Yamaguchi, and Kenichiro Itami
The 4th Global COE in Chemistry Annual Synposium, P-28, Nagoya University, Jun 15, 2011.