Kazuya Yamaguchi, Junichiro Yamaguchi, Armido Studer, and Kenichiro Itami

Chem. Sci, 2012, in press. DOI:10.1039/C2SC20277H

A new Pd-catalyzed C–H/C–B coupling of sterically hindered heteroarenes and arylboronic acids has been identified. The newly established Pd(OAc)2/bisoxazoline/TEMPO system not only enables the synthesis of sterically hindered heterobiaryls but also offers an opportunity for enantioselective biaryl coupling through C–H functionalization.